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Cervical lymphadenopathy was absent. Two deep punch biopsies 4 mm showed a poorly circumscribed, deeply infiltrative tumour with basaloid aspect and perineural invasion confirming MAC.

The patient underwent surgical excision with 1. Histopathology revealed an lateraly and deep incomplete removed tumor R1 infiltrating the muscle bundles with perineural invasion.

A second stage surgery was necessary with lateral and deep enlarging of the defect including the removal of the frontal periostium.

Clear histological margins were achieved and the final surgical defect was 6 x 7 cm. The eyebrow defect was finally reconstructed by a modified AT flap combined with full thickness skin transplantation 56 Poster of the flap dog ears.

The cosmetic outcome was satisfactory, no occurrence was observed after 9 moth follow-up. Conclusion: We confirm the histological difficulties diagnosing this tumour entity and the deep infiltration of MAC.

Removal deep including the periostium might be necessary to completely remove the tumour. They are characterized by aggressive local infiltration but rarely metastasize.

Local recurrence invariably follows inadequate removal. Surgery remains the first-line treatment for both sarcomas and wide surgical excision with a margin between 2 and 4 cm has been recommended.

Mohs Micrographic Surgery has been reported as effective in reducing the rate of local recurrence. Immediate reconstruction with autologous split-thickness skin graft STSG secured by negative wound pressure therapy VAC was performed in all cases.

One case received a porcine xenograft EZ Derm on top of the free Achilles tendon prior autologous split-thickness skin grafting.

Application of STSGs instead of flap surgery was performed because it allows immediate closure and fast recognition of local recurrence.

Results: All patients achieved tumor free margins with the first surgical intervention. No local recurrence or distant metastasis occurred Median follow up Functional results were all good and the esthetic outcome was satisfactory.

Because of the lack of excess skin in the areas between the lip and nose, many reconstructions for this area use medial cheek advancement flaps.

Superficial defects of the lateral upper lip may be closed primarily according the skin tension lines and defects closer to the nasolabial fold may be closed primarily within this fold 1.

Case report: In the present article the authors discuss a year-old man who presented to Dermatology Service with a basal cell carcinoma located on the right lateral upper lip.

Tumor size was 12x12 mm; the lesion was excised with security margins determined by polarized light epiluminescence dermoscopy.

The final surgical defect size was 15x18 mm. Results: Although transgressing the facial subunits, eight weeks after surgery, this subcutaneous advancement flap provided a good functional and aesthetic acceptable reconstruction.

The typical presentation is with solitary or few rapidly growing erythematous or bluish plaques or tumors on one leg rarely both legs.

Plaques and tumors may even ulcerate and may be clinically difficult to differentiate from venous leg ulcers.

Methods: We describe for the first time 3 patients with pcDLBCL and an atypical early presentation characterized by macules instead of plaques, tumors or ulcers.

All three patients reported a history of long standing lesions since 6, 9 and 18 months, respectively without a history of rapid enlargement.

Conclusions: pcDLBCL,leg may rarely manifest at presentation with annular erythematous macules instead of plaques or tumors simulating granuloma annulare, necrobiosis lipoidica, sarcoidosis, erythema chronicum migrans, erythema annulare centrifugum or erythema marginatum.

Inoperable Tumoren wurden bislang bestrahlt. Einleitung einer Therapie mit Vismodegib im Februar Allerdings kam es im 5.

Behandlungsmonat zum neuerlichen Tumorwachstum. Bereits nach 1 Monat deutliche Tumorregression, nach 5 Monaten war weder klinisch noch bioptisch Tumorgewebe nachweisbar.

Aim of this study was evaluation of 11 body areas for predicting hirsutism in Kosovar population. Materials and Methods: In this prospective diagnostic study we selected women, with hirsutism and 25 as control group, age years.

Height, weight and a calculation of BMI was obtained. The Ferriman-Gallwey score is used in evaluation of hirsutism. The examiner scored the subjects on a scale of for terminal hair growth on eleven different body areas according to the Ferriman-Gallwey FG scoring system.

An FG score of 8 or more was considered diagnostic of hirsutism. A thorough physical examination with specific emphasis on signs of virilization including frontal baldness, loss of female body contours, increased muscularity, acne, clitoromegaly, and atrophy of breast was done in all patients.

Results: The age group with highest scoring were women under 20 years and age group years on average value The range of average scoring in different parts of the body was: 3.

Conclusion: The FG scoring system was found to be clinically useful. The feet, thighs, arms and chin were observed to have the highest score of androgen sensitive area of the body.

The FG scoring system has great significance and value to establish the diagnosis of hirsutism and is an acceptable screening method.

Key words: hirsutism, evaluation, Ferriman-Gallwey score. In prior studies, the most common treatment emergent neuropsychiatric adverse events for ATR included abnormal dreams and dizziness.

W96 safety and efficacy were secondary endpoints presented here. Conclusion: EPA demonstrated non-inferior efficacy and a favorable safety profile versus ATR with fewer discontinuations due to adverse events and fewer neuropsychiatric adverse events including abnormal dreams and dizziness.

We report the safety and tolerability profiles of STB vs comparators through W Methods: We report results from prospective, randomized, open-label, Phase 3b trials of regimen switching to STB.

STB was safe and well-tolerated with similar rates of AEs. Liu 10, David Piontkowsky 10, Martin S. Similar to ritonavir, cobicistat inhibits renal creatinine secretion, leading to a small increase in serum creatinine, without affecting the actual GFR.

Results: Rates of renal discontinuations were STB 1. Of those, 0. All PRT cases improved after study drug discontinuation. Tubular abnormalities were similar between treatment groups regardless of baseline eCrCL.

Insgesamt wurden Patienten getestet, an der Klinik und im niedergelassenen Bereich. Eine Aufnahme dieser Erkrankungen in eine nationale Leitlinie ist anzustreben.

Capecitabine as well as the widely used blood pressure regulating angiotensin converting enzyme inhibitors ACEIs are prone to cause severe coutaneous side effects.

In the present study, we sought to evaluate the potential influence of ACEIs on the appearance and severity of capecitabine-induced HFSR in breast cancer patients.

Patients who received chemotherapy bevacizumab and capecitabine and treatment with ACEIs were evaluated for incidence and intensity of capecitabine-induced HFSR.

Results: HFSR was observed in In South Tyrol a threepart triage system to gain faster treatment for urgent and emergent cases of dermatology outpatients has been introduced by the Provincial Government.

The defined threepart triage levels are urgent, priority and deferrable with a corresponding maximum time target before treatment of 1, 8 and 60 days respectively.

Methods: from February to August a sample of outpatient electronic medical records cases were randomly retrieved. Referral diagnoses with their corresponding triage codes were recorded.

Urgent visits were further analyzed according to the referring physician. The appropriateness of the referral was determined on the basis of the published state law diagnostic guidelines.

Data were statistically analyzed using the 2-tailed Pearson Chi2 test or the Fisher exact test. Results: Overall, Conclusion: The triage system according to clinical need is safe, no urgent cases are overseen.

Frequency of diagnoses differ significantly in the three triage levels, this in general points to an operating allocation system.

In the north Italian province of South Tyrol waiting times for non urgent dermatological specialist referrals and requests for specialist care are monitored centrally by the local government.

Methods: We performed a retrospective study regarding the correlation between monthly waiting time and number of access requests for the city of Bolzano, where the basin comprises approximately The monitored time included data from November to July provided by the central monitoring agency.

Results: The results of the analysis showed that the median waiting time for a non urgent dermatology referral was 57 days in the first year of the monitoring and was slowly increasing: it was 30 days at the begin of the year and 61 days at the end of the year.

Due to staff shortage waiting time increased sharply at the end of until reaching a maximum of days in January With the allocation of new physicians, waiting time then decreased to 49 days in July Not surprisingly waiting time correlates strongly negative with requests for access in specialist health care.

Allocation of adequate human resources reduces waiting time, but augments requests for specialist consultations. Anamnestisch starker Nicotinabusus.

Neben einer Psoriasis vulgaris wird auch die Verdachtsdiagnose eines Bazex-Syndrom gestellt und eine Tumor-Suche begonnen.

Epicutantest und Pilzkultur blieben ebenfalls ohne Ergebnis. Diskussion: Die Acrokeratosis paraneoplastica Bazex ist eine sehr seltene, obligate Paraneoplasie und tritt vor allem im Zusammenhang mit Plattenepithelkarzinomen des aerodigestiven Traktes auf; in der Literatur findet sich jedoch auch ein Auftreten bei anderen Neoplasien, z.

Beschrieben wurde das Bazex-Syndrom bisher v. Die typische Klinik umfasst schuppende, unscharf begrenzte, symmetrische, psoriasoforme Erytheme an den Akren sowie distale Hyperkeratosen und Rhagaden.

Weiters sind typisch eine Onychodystrophie, sowie Hyperkeratosen an den Ohren, und evt. LE-artige Gesichts-Erytheme.

Als Differentialdiagnosen kommt neben einem Ekzem vor allem eine Psoriasis palmoplantaris vom keratotischen Typ in Frage. Die Pathogenese ist weitgehend unbekannt.

Die Therapie liegt in erster Linie in einer Malignomsanierung. Bull Soc Franc Derm Syph, Acrokeratosis paraneoplastica Bazex syndrome. JEADV, Therefore, we studied the expression and localization of those and other inflammation and fibrosis markers in scarring and non scarring skin of RDEB patients and healthy donors by sqRT-PCR, immuno blots, and IF microscopy.

Conclusion: Our results point to an important role of inflammation and fibrosis in impaired wound healing, finger contractures and pseudosyndactyly in RDEB.

The role of myofibroblasts is unclear. This study revealed potential therapeutical targets to improve wound healing and finger contractures in RDEB.

Reportedly, topical antibiotics, corticosteroids and calcineurin inhibitors only have temporary efficacy.

Patients and methods: Four male patients with a history of surgical and conservative topical treatment for in situ squamous cell carcinomas of the scalp, were admitted because of recurrent pustular flares, erosions and crusts restricted to the bald scalp, recalcitrant to multiple topical therapies.

Direct immunofluorescence was negative in all. Results: After initial improvement all pts developed recurrences under consecutive dapsone therapy, thus it was discontinued after four weeks.

In contrast, subsequent treatment with a topical classsteroid mometasonfuroat induced complete remissions within weeks, but all pts developed relapses following cessation of therapy.

Nevertheless, all recurrences could rapidly be managed by reintroduction of this regimen, moreover, further relapses were completely prevented by intermittent application of mometasonfuroat times per week.

Conclusion: Here we show that topical treatment with dapsone-gel was not effective in our pts. Dramatic improvement was achieved with a topical classsteroid, but long term remissions required continuous, intermittent therapy, which underscores the recalcitrant nature of the disease.

Since surgical treatment in one pt led to a long lasting disease free period, this approach may represent an interesting alternative in severe cases.

Pathogenesis is poorly understood and the clinical course of PG is impredictable. The disease might regress spontaneously, stay inactive for months or progress and worsen after trauma, surgical interventions or even without triggers.

No gold standard has been established for the treatment of PG. The role of surgical interventions and Negative Wound Pressure Therapy NWPT is controversially discussed in the literature as these procedures might pose a trigger to further aggravate the condition.

Material and methods: We report 10 consecutive patients affected by PG, three males and six women median age 65, range from 26 - The extremely painful ulcers were all situated on the lower extremities, except of one case of post augmentation mastopexy pyoderma and measured from 8 x 4 cm to 45 x 25 cm.

All patients were hospitalized prior to surgical intervention and received methylprednisolone and in most cases further immunosuppressive or immunomodulatory therapy including dapsone, ciclosporine, infliximab, methotrexate or pentoxyphylline.

NWPT was applied up to one week prior further surgical interventions. Gentle surgical debridement of the wound bed and wound borders was performed in local tumescence anesthesia and 0,3 mm thickness skin grafts STSG were transferred and secured by NWPT.

One case was not grafted because it showed fast intrinsic healing with good epithelialization under NWPT and the mammary case was grafted without applying NWPT.

All cases of PG did markedly improve with the application of NWPT, as with the surgical intervention, no case of pathergy was observed, neither from application of NWPT nor from skin grafting.

Discussion: This is the largest case series of surgical treatment for PG reported in the literature. Blister formation can also be induced via autoimmune reactions directed against self antigens as known for bullous pemphigoid.

In either case the structural integrity of the integument is affected, which leads to blistering. The primary genetic causes of epidermolyis bullosa may induce secondary effects that aggravate the disease phenotype by activating the expression of factors that degrade extra-cellular matrix components and thereby further weaken the structural integrity of the skin.

Methods: We analysed the gene expression profiles of patient derived EB-simplex Dowling-Meara cell lines in vitro as well as the composition of blister fluids of different EB subtypes in vivo.

Results: Gene expression profiles of EB-simplex Dowling-Meara cell lines revealed increased expression of matrix metalloproteinase-9 and interleukin We identified high levels of these two factors in all blister fluid samples compared to healthy controls.

Due to the fact that these two factors are causally responsible for blister formation, and that they are also expressed in high levels in epidermolysis bullosa skin, they constitute potential therapeutic targets for small molecule based therapies.

Nevertheless, they both exhibit increased plasma IgE and numbers of mast cells in the upper dermis, indicating an atopic predisposition.

Women with PCOS may have enlarged ovaries that contain small collections of fluid -called follicles -located in each ovary as seen during an ultrasound exam.

Infrequent or prolonged menstrual periods, excess hair growth, acne, and obesity can all occur in women with polycystic ovary syndrome.

It is well known that hyperandrogenism and insulin-resistance with or without compensatory hyperinsulinism are closely associated, but the Rotterdam Consensus has concluded that principally obese women with polycystic ovary syndrome PCOS should be evaluated for the metabolic syndrome.

We present the case of 24 year old female patient with hirsutism. She was underweight, had acne and positive family history for hirsutism and diabetes.

She was evaluated to identify etiology, and was diagnosed as a case of PCOS with insulin resistance. It is very rare case when PCOS women with insulin resistance is underweight.

She was treated according to underlying pathology and improvement was significant after 6 month. Etablierte Therapien der GM umfassen Methotrexat ev.

Die Evaluierungen erfolgten vor Therapiebeginn Baseline sowie unmittelbar und sechs Monate nach Therapieabschluss. Ergebnis: Unmittelbar nach der Therapie war der Bewegungsumfang nahezu aller Gelenke verbessert.

Die Handkraft hingegen nahm weiter zu li. Weiters konnte ein nachhaltiger Effekt bis 6 Monate nach Therapieende beobachtet werden. Sie sind zumeist durch hohe Temperaturen gekennzeichnet.

Differentialdiagnostisch wurden Diabetes mellitus, eine Venenthrombose, eine Uveitis sowie ein Irvine-Gass-Syndrom ausgeschlossen.

Dies unter anderem durch die Inhibition von NK-kB. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol.

Br J Dermatol. Dimethylfumarate is a potent inducer of apoptosis in human T cells. J Invest Dermatol. J Immunol. Suppression of VEGFR2 expression in human endothelial cells by dimethylfumarate treatment: evidence for anti-angiogenic action.

Fumarate esters as angiogenesis inhibitors: key to action in psoriasis? Leonardi C et al. Louis University School of Medicine, St. LY Greater clinical response is associated with improved patient reported outcomes: results from a phase 2 study in patients with moderate to severe psoriasis treated with ixekizumab.

The pathogenesis of Schnitzler-Syndrom is currently under investigation and is supposed to be related to excessive interleukin-1, which is further evidenced by the good and rapid clinical response to ILblockade.

Methods: A year old female patient suffered from intermittent urticaria combined with fever and strong arthralgia as well as increased levels of CRP since Over the years a lot of diagnostic investigations were done without concrete findings, and therapuetic attempts with anti-histamines and classical immunosuppressants failed.

The decision to start monotherapy with interleukin-1 receptor antagonist anakinra; mg subcutaneously every 24 hours was made in October At that time the patient had severe symptoms and histology revealed a leukocytoclastic vasculitis, compatible with urticaria-vasculitis for the first time.

After starting anakinra, symptoms disappeared within 24 hours. An interruption of therapy in November resulted in a rapid return of symptoms.

These suggested the diagnosis of Schnitzler-Syndrom. Today, 5 months after starting continuous therapy with anakinra, the patient is free of symptoms and beside mild dermatitis at the injection site no adverse drug effects have been registered.

Results: Monotherapy with the interleukin-1 receptor antagonist anakinra is a highly effective therapeutic option in Schnitzler-Syndrom.

Other IL-1 inhibiting agents, such as rilonacept, are currently under investigation. Rezente Erkenntnisse zeigen uns, dass Psoriasis eine Systemerkrankung ist.

Seit ca. In den abgenommenen Blutkulturen kam es zum Wachstum von E. Unter Antibiotikatherapie Ciprofloxacin i. Aufgrund des klinischen Verlaufs wurde von weiteren invasiven Untersuchungen Abstand genommen.

Schlussfolgerung: Da es sich bei Psoriasis um eine Systemerkrankung handelt ist ein Zusammenhang mit neutrophiler Cholangitis sehr wahrscheinlich.

Literatur: 1 P. Dieude, E. Sbidian, M. Viguier, E. Zafrani et al. Neutrophilic cholangitis in psoriasis vulgaris and psoriatic arthritis.

British Association of Dermatologists ; , 2 M. Allez, ME Roux, P. Bertheau et al. Recurrent cholestatic jaundice associated with generalized pustular psoriasis: evidence for a neutrophilic cholangitis.

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Two block busters currently being marketed are: the active ingredients Interferon gamma and tumour necrosis factor alpha.

The latest innovation is a new kind of biofermenter for high cell-density fermentation of bacteria and yeasts.

The most important institute in Austria that works with molecular biology performs research on a variety of subjects, such as the development of cancer cells, and it has earned an excellent reputation among international experts in the field.

These two institutes, which belong to the Austrian Academy of Sciences perform basic research. Sandoz GmbH formerly Biochemie GmbH and a member of the Novartis Group , with development and manufacturing operations in Kundl and Schaftenau, has 2, employees and is the leading company for pharmaceuticals and generics in Austria.

Enzymes, hormones and therapeutic proteins are manufactured in Kundl. On January 31, , Nabriva Therapeutics Forschungs GmbH, a biotechnology firm which focuses on antibiotics, opened its doors.

Nabriva concentrates on developing antibiotics for hospital-acquired infections and has an extremely solid pipeline of antibacterial active agents.

At present, three projects are at an advanced preclinical stage, and one product will soon be in clinical phase 1. The Campus Vienna Biocenter VBC is the product of a smoothly functioning symbiosis of the private sector and both university and non-university research institutes.

The Intercell company, founded in and now listed on the stock exchange, is located at the Campus Vienna Biocenter.

Vaccines used to treat diseases such as tuberculosis are developed here. Thanks to financial support provided by partners around the world and the licensed projects of Chiron and Intercell, Pelias intends to develop new kinds of vaccines and treatments based on antibodies.

Another success at the Biocenter is VBC-Genomics Bioscience Research GmbH, which turns patented biochip expertise into marketable products for diagnosing allergies in connection with hormone-replacement therapy.

The Novartis Institutes for BioMedical Research Austria, Vienna NIBR has been one of the most important centres in Austria for pharmaceutical research since ; at present, as a centre of excellence for dermatology, it performs research on innovative treatments for inflammatory skin conditions including neurodermatitis and related allergies and immunodeficiencies for the Novartis group.

Late in , Austrianova received credit guarantees totalling 3. Lambda GmbH of Upper Austria develops and manufactures biochips for diagnostic applications in addition to working with bioanalysis and various kinds of DNA analysis.

The company also provides DNA sequencing and validation of test methods in the form of commissioned research.

Also noteworthy are biotechnological products, which are sold primarily for the manufacture of nutritional supplements.

Another item made for the food industry is the thickener xanthan gum. Solely Maize Technologies International concentrates on crops. Numerous other firms develop projects in the field of biotechnology, and they now occupy a firm position in the sector.

Both established companies and biotechnology start-ups, most of which are active in biopharma, comprise its membership. The unanimous opinion of economic experts is that Austria will benefit more than any other EU member from the most recent enlargement, thanks to its longstanding commercial ties to new member states.

There is much to learn about Austria as a business location. General information and support can be obtained from the Austrian Business Agency www.

Among the EU, only Ireland offers more favourable tax provisions. However, Austria also makes a strong showing in comparison to the new EU member states that are attracting investors through major tax reductions.

Research and training exemptions, deductions for losses and the carryover of silent reserves are also resulting in significant reductions.

Companies will benefit from the group taxation relief: under the new provisions, the profits and losses of domestic group members are offset along with the losses of foreign subsidiaries, which reduces the basis for calculation of the corporate tax.

Investments in the form of silent partnerships enjoy tax advantages under Austrian law and also play an important indirect role in subsidising and financing commercial research and development.

Support and assis- austriantrade. LISA draws on many years of experience in the life sciences to put this expertise at the disposal of potential new businesses.

It provides help in drawing up business plans and conducting market research and analysis. Advice on patent law, assistance in identifying joint-venture partners and financiers, and a suitable infrastructure are also made available.

Mezzanine loans enable start-ups of young biotech companies with an established technological foundation and high growth potential seed financing.

Both forms of financing are intended to help bridge the interval between start-up and the availability of risk capital.

Venture-capital investments can then be backed by Austrian guarantees: as companies mature, aws provides loans at competitive rates and growth financing in the form of guarantees for business investments.

Oppenheim, Alpinvest 27 mil. A welcoming business environment, a prime location at the heart of Europe and its high quality of life all contribute to leveraging biotech growth in the country.

Beyana Maghakian A ustria is not only famous for musicians such as Wolfgang Amadeus Mozart, whose th birthday is being celebrated in the year ; the field of medicine has always possessed great significance here.

For centuries, the persistent innovative spirit of Austrian scientists has led to numerous discoveries which represent milestones in medicine, biology, chemistry and other scientific fields.

In , Ignaz Semmelweis for the first time introduced antiseptic measures for the prevention of childbed fever.

Toward the end of the 19th century, Theodor Escherich discovered the most important bacterium used in biotechnology, Escherichia coli. And in , Karl Landsteiner identified the blood groups, which earned him the Nobel Prize.

Companies like Eli Lilly and Roche are important research contractor for the academic community in Austria.

With the aim of satisfying the daily needs of hospitals and medical practitioners, a number of small and medium-sized companies develop diagnostic tools, innovative services and novel treatments.

In contrast to the concentration in red biotechnology, the plant and environmental sector can be described as rather small.

In total, the country hosts about small and austriantrade. Biotech products increase in importance Despite being an infant industry just 30 years old, the global biotechnology sector can look back on an impressive record of success.

Numerous success stories have already been written there, and these locations are still the places to look for vibrant activity.

Recently, Upper Austria and Lower Austria have also turned their attention to biotechnology. Applications of biotechnological knowledge will in the near future dominate most areas of daily life.

There are more than , students currently studying and researching at its nine universities, and all the life sciences are covered at five of them.

Nevertheless, the medical field clearly dominates, with cancer research, immunology and dermatology being the most outstanding areas.

Multinational enterprises such as Baxter, Boehringer Ingelheim, Novartis and top-ranking biotech and medtech companies as well are taking advantage of this environment.

Since , there have been approximately around 50 biotech start-ups, the majority focusing on red biotechnology.

Together with the big players, these research-oriented enterprises employ about 6, people. The successful flotation of Vienna-based Intercell in spring marks the beginning of a new era for bioindustries in Austria.

Other start-ups have already managed to attract considerable amounts of risk capital, the most recent examples are Nabriva focusing on novel antibiotics, Fibrex, which specialises in the treatment of reperfusion damage, and Biovertis.

Austrianova has been granted orphan drug status by European Medicines Agency for its medication designed to treat pancreatic cancer. And TissueGnostics has developed an innovative system for analysing whole cell groups and tissue samples which will be used in routine diagnostics.

Strong support is provided by federal and regional authorities. Austria Wirtschaftsservice www. Working in a holiday region: biotech in the Tyrol Tyrol is known throughout the world as an excellent place for a holiday.

The research performed in the fields of cell engineering, implant and implantation technology, medical device, health and bioinformatics, bioanalytics and drug delivery enjoys international renown.

Tyrolean life-science companies benefit from academic know-how. For example, the AlcaSynn Pharmaceuticals company develops opioid receptor blockers for use in pain therapy.

Thiomatrix utilizes thiolated polymer systems for mucosal delivery of biomolecules such as polypeptides, and Innovacell works on new cell-therapy processes to replace damaged muscle tissue.

The health informatics company Icoserve designed an advanced image-management software solution for hospitals. Over the past few years, about 50, square metres of lab and office space have been provided by public authorities.

Part of this organisation is the Competence Centre Medicine Tirol, where researchers and entrepreneurs are currently collaborating on a total of 19 projects.

Healthcare technology in Styria: medical devices, white biotechnology and regenerative medicine In Styria, the biotech scene is small but very dynamic.

ProtAffin, a KarlFranzens University spin-off, develops genetically modified proteins for treating inflammatory illnesses. Transgenic animal models employed in the study of neurodegenerative diseases is the speciality of JSW Research, also based in Graz.

White biotechnology and upscaling technologies are rapidly growing in Styria. Total healthcare solutions, including testing facilities, are made available at the Center For Medical Research, where their partners perform clinical trials phases The enormous potential of the network results from its unique density of competence.

Political Commitments human. Currently, we cooperate with Austrian institutions and companies as well as institutions in the South-Eastern markets and with selected international partners.

Welcoming business environment, high quality of life and a prime location in the heart of Europe contribute to leveraging growth in the region.

Together with universities, research institutes and the big players on site they form a thriving Life Science community.

Extensive know-how and potential among companies and research bodies Upper Austria is the leading federal province with regard to commerce, industry and exports.

Moreover, the role of biosciences and biotechnology in Upper Austria is to be massively enlarged. Expansion in the education and research areas Education and research are of fundamental importance.

Close integration of business into the Life Sciences strategy For Upper Austria, four areas of application are of major significance.

The predominant factor in this regard is medical technology, which is to be the object of expansion.

Almost companies are active in this economic segment. The competent further development of foods technology is an important factor in international competition.

Keywords: functional food, proteins, lactose, enzymes, etc. Around enterprises are involved in this rapidly expanding, internationally oriented sector.

Biotechnology is supplying impulses for production innovations such as filter membranes in wastewater and waste treatment.

Interesting areas of application in the Life Sciences field include process technology in the chemicals and pharmaceuticals sectors, as well as in the paper industry.

Positive preconditions for commerce and industry. Companies planning to enter this sector find an excellent framework provided by the Health and Foods Clusters and the Environmental Technology Network.

Companies are assisted in their activities and on the path to new technologies and international markets. In summary, it can be stated that the Life Sciences sector is booming, the preconditions are positive and an entry into the area will pay off.

Technopol Krems The city of Krems is pursuing an emphasis on biomedicine tissue engineering, cellular therapies, extracorporeal blood purification and healthcare services.

And the best evidence that they are the right directions is the host of international businesses striving for Krems. Technopol Tulln The Technopol Tulln focuses intensively on research and development in the fields of agro- and environmental biotechnology.

Biotechnical processes are developed in the areas of plant and animal production, as well as environmental protection.

More than highly specialized researchers are already active on-site. The Research Institute for Agro-Biotechnology IFA Tulln , a Department of the University of Natural Resources and Applied Life Sciences in Vienna, ranks among the leading research institutes in Europe in the fields of biotechnology in animal and plant-production, bioanalytics, environmental biotechnology and technology of natural materials.

Harald Gohm T. Nevertheless, when we speak of Tirol as a business location, there is one thing we should not forget: apart from tourism, Tirol has developed into a specialised high-tech location.

Tirol as a business location - mountainous habitat, healthy business The Tirolean economy has a small structure. Thousands of small and medium-sized companies operate in the various areas of the production, trade and service industries.

The balanced representation of industry guarantees healthy economic growth. Tirol leads the way in Austria with 1. The gross value added in Tirol was approximately Next to small and medium-sized companies, the larger domestic companies are also responsible for this.

These larger companies impress worlwide with their know-how and high level of quality. The Tyrolean Life Science Research fields of cell engineering, implant- and implantation technology, medical device, health- and bioinformatics, bioanalytics and drug delivery are internationally established.

The first industrially manufactured Penicillin was made in the small village of Kundl. Ideal transport connections make Tirol a hub for the international exchange of goods and knowledge.

Tirolean Fortitude Along with the exceptional position of its location, Tirol offers an economic area with further advantages for companies and employees.

Three universities, two colleges of higher education and also technical schools ensure an excellent standard of education. Professional customer-orientated administration and politicians who act as direct contacts for economic matters guarantee flexible and uncomplicated bureaucratic procedures.

In combination with the high standard of living, these are noticable advantages for a location. The combination of qualified jobs and optimal leisure time possibilities, embedded in unique natural surroundings, attract top international executives to Tirol.

Are you interested in further information? Agneter has dealt with preclinical and clinical expert reports for marketing authorization of medicinal products.

Agneter was appointed Medical and Marketing Director of an international pharmaceutical company in Austria. As pricing and reimbursement questions are gaining importance and complexity, Agneter PharmaConsulting provides a full service in working out strategies and preparing reimbursement dossiers.

Agneter is working with several pharmaceutical companies. In Agneter PharmaConsulting was founded with the scopes of clinical expert reports, drug evaluation, pricing and reimbursement and strategic advice on clinical trails.

We focus on the development and manufacture of microbial derived biopharmaceuticals, such as proteins, plasmid DNA, antibody fragments and protein scaffolds.

In state-of-the-art GMP facilities we manufacture products for clinical trials and market supply. Boehringer-Gasse A Vienna T. Also in , we received the Customer Value Award for providing our international clients with the highest quality customer manufacturing.

Value through Innovation. Products are highly purified in modern recovery and purification units. Columns up to 1. Explosion-proof areas allow steps requiring the use of organic solvents or large scale high performance liquid chromatography.

Located on the campus of the University of Veterinary Medicine Vienna and having its roots in the Institute of Bacteriology, Mycology and Hygiene, a university institute which is internationally recognised for its research on mycoplasmas, Mycosafe is well-positioned to become a mycoplasma testing service center and developer of new mycoplasma testing assays of the future.

Since December , Mycosafe is operating under the new name Mycosafe Diagnostics GmbH and is today considered as a leading contract service and research organisation which plays an important role in the success of its clients in research and biopharmaceutical production by assuring the mycoplasma biosafety of cell banks, in-process samples, lot-release samples and raw materials.

Mycosafe also offers PhEur and US FDA compliant validation studies to qualify each mycoplasma testing assay for the respective product to be tested.

In addition, Mycosafe offers its expertise in mycoplasma species identification and strain characterisation using molecular techniques, and also provides consultancy and training services in the area of mycoplasmology.

In cooperation with academic and industrial partners, Mycosafe is developing and validating new innovative DNA-based testing systems for the detection and identification of mycoplasmas.

Both of these substances are approved as human drugs and are commonly used in hospitals. The drug is easy to use and the therapeutic dose has no significant side effects.

To the present day 16 countries have participated in the UACI research with more than scientists in 46 universities and research institutes.

The results of UACI research are regularly presented on international congresses and published in scientific magazines.

Reading about that, one wonders if this discovery is suppressed because it is against some pharmaceutical companies' interests.

Our products target segments characterised by both unmet medical need and interesting revenue potential.

This encompasses developmental skills, regulatory procedures and the synthesis of complex APIs and forms the key to a range of longterm competitive advantages.

The majority of our revenues are already generated through product sales. We consciously avoid broad-based and cost-intensive exploratory research.

Extensive in-house skills and resources are supplemented by numerous top-level scientific co-operations with contract research organisations, institutes and universities.

Profitable contract manufacturing orders, API synthesis and imaging diagnostic sales all contribute to steady revenue flows. Additional potential lies in pipeline developments of new drugs for attractive segments of the pharmaceutical market.

This in turn allows us to offer partners a wide range of services in the fields of contract synthesis and manufacturing.

We use our experience and knowledge to help clients to set up a mycotoxin control system and to manage the risk.

Romer Labs Diagnostic GmbH www. However, the purity of mycotoxin standards is often uncertain. Founded in the year , Biopure has developed world-leadership in the production of highly purified mycotoxin calibrants.

Today thousands of labs in all continents benefit from the liquid and solid calibrants supplied from Biopure. Because of new regulations, the testing of mycotoxins has become very important also for remote places, where no Labs can be established.

Vitateq was the first to discover that afamin, a human serum transport protein for vitamin E, is a major player in the development of reproductive tract tumors, infertility and neurodegenerative diseases.

Presently, there are no comparable products available on the market. Afamin exerts neuroprotective properties in neuronal cell culture models.

These results indicate a high potential for diagnostic and therapeutic applications of afamin not only in the fields of fertility and cancer, but also neuroprotection.

Vitateq has established an ELISA kit for quantifying afamin in human serum as a novel diagnostic tool for early, improved and more specific detection of cancers occurring in human reproductive tissues.

This ELISA kit is fully developed and has already been tested successfully in several human patient groups. Vitateq Biotechnology is a spin-off company from the Medical University of Innsbruck with international management.

Our product development is protected by several international patents. Our new diagnostic test will be based on a variety of significant and biologically relevant biomarkers.

Biochemistry Core competence of the company is to study changes of gene expression and function in human tissues during cancer development and ageing, with the intention to identify and validate new targets for early diagnosis of tumour-, age- and environmentinduced diseases.

The products are currently in preclinical trials. At present, cervical cancer screening is the largest existing screening market in oncology.

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